Al Strobel ......Philip Michael Gerard/Mike/The One-Armed Man
Annette McCarthy ......Evelyn Marsh
Austin Jack Lynch ......Pierre Tremond
Billy Zane ......John Justice Wheeler
Brenda E. Mathers ......Caroline Powell Earle
Brenda Strong ......Jones
Carel Struycken ......The Giant
Carol Lynley ......Diane, Cooper's secretary
Catherine E. Coulson ......The Log Lady/Margaret
Charlotte Stewart ......Elizabeth Briggs
Chris Mulkey ......Hank Jennings
Clarence Williams III ......Roger Hardy
Clay Wilcox ......Bernard Renault
Dan O'Herlihy ......Andrew Packard
Dana Ashbrook ......Bobby Briggs
David Duchovny ......DEA Agent Dennis/Denise Bryson
David Lynch ......Agent Gordon Cole
David Patrick Kelly ......Jerry Horne
David Warner ......Thomas Eckhardt
Don Amendolia ......Emory Battis
Don S. Davis ......Maj. Garland Briggs
Eric Da Re ......Leo Johnson
Everett McGill ......"Big Ed" Hurley
Frances Bay ......Mrs. Tremond
Frank Silva ......Bob
Fumio Yamaguchi ......Tojamura
Galyn Gorg ......Nancy O'Reilly
Gary Hershberger ......Mike Nelson
Gavan O'Herlihy ......RCMP Officer Preston King
Grace Zabriskie ......Sarah Palmer
Hank Worden ......The Waiter
Harry Goaz ......Deputy Andy Brennan
Heather Graham ......Annie Blackburn
Ian Buchanan ......Richard Tremayne
Jack Nance ......Pete Martell
James Booth ......Ernie Niles
James Marshall ......James Hurley
Jan D'Arcy ......Sylvia Horne
Jane Greer ......Vivian Smythe
Jessica Wallenfells ......Harriet Hayward
Joan Chen ......Josie Packard
John Apicella ......Jeffrey Marsh
Joshua Harris ......Nicolas 'Little Nicky' Needleman
Julee Cruise ......Herself
Kenneth Welsh ......Windom Earle
Kimmy Robertson ......Lucy Moran
Kyle MacLachlan ......Dale Cooper
Lara Flynn Boyle ......Donna Marie Hayward
Lenny Von Dohlen ......Harold Smith
Mae Williams ......Mrs. Tremond
Maedchen Amick ......Shelly Johnson
Mak Takano ......Jonathan Kumagai
Mary Jo Deschanel ......Eileen Hayward
Michael Horse ......Deputy Tommy "Hawk" Hill
Michael J. Anderson ......The Dwarf
Michael Ontkean ......Sheriff Harry S. Truman
Michael Parks ......Jean Renault
Miguel Ferrer ......Agent Albert Rosenfield
Nicholas Love ......Malcolm Sloan
Peggy Lipton ......Norma Jennings
Phoebe Augustine ......Ronette Pulaski
Piper Laurie ......Catherine Packard Martell
Ray Wise ......Leland Palmer
Richard Beymer ......Benjamin Horne
Robert Bauer ......Johnny Horne
Robyn Lively ......Lana Budding
Russ Tamblyn ......Doctor Lawrence Jacoby
Sherilyn Fenn ......Audrey Horne
Sheryl Lee ......Madeleine Ferguson/Laura Palmer
Victoria Catlin ......Blackie O'Reilly
Walter Olkewicz ......Jaques Renault
Warren Frost ......Dr. William Hayward
Wendy Robie ......Nadine Hurley